A Savannah man died after crossing the center line and causing a four-vehicle crash Thursday on Highway 21 near Highway 275, according to the Georgia State Patrol.

A Life Star helicopter landed on Highway 21 and airlifted Carlton Anderson, 66, to Memorial Health University Medical Center, where he died.

Two other drivers were injured in the crash. Barbara Richter, 60, of Springfield was taken by ambulance to Memorial, and Matthew Kessler, 49, of Springfield was treated at Effingham Hospital.

According to the State Patrol report, Anderson was driving north on Highway 21 and his Buick Regal crossed the median and into the southbound lanes. The car then went back and forth between the median and the southbound lanes for approximately 1,700 feet, the report states.

Richter had stopped for a red light at the intersection of Highways 21 and 275, and her Saturn Outlook was hit head-on by Anderson’s car. The impact pushed Richter’s car backward into a Volvo XC70 driven by Kessler.

Anderson’s vehicle hit another car, a Ford Explorer driven by Maria Martin, 47, of Springfield. Martin and her two passengers were not injured.

According to investigators, evidence along Highway 21 showed Anderson’s car first went into the median nearly a mile ahead of where the crash occurred.

“One of the witnesses … stated he observed (Anderson’s car) make contact with the guardrail on Georgia 21 northbound, just north of Rincon Elementary School,” the report states. “All the other witnesses listed on this report stated they observed (the car) traveling northbound in the southbound travel lanes.”

The GSP report does not state any medical issues or other factors that might have contributed to Anderson losing control of the car and causing the crash. Autopsy results are pending.